Jalview's services will be unavailable from 17:00 GMT on Thurs 9 Dec until 9:00 on Monday 13 Dec 2021.

The downtime is due to major network engineering, and affects all of the Jalview and Barton group web servers.
If you urgently require Jalview analysis services during this period, we recommend you install the JABAWS virtual appliance and configure your Jalview desktop preferences so it can access it.

Looking into DNA & RNA Activity

Viewing DNA in Jalview

DNA (deoxyribonucleic acid) is a key molecule in nature. It is made up of two extremely long strands arranged in a spiral.
The DNA helix resembles a spiral staircase, with the steps of the staircase being the 4 different DNA bases: adenine [A], guanine [G], cytosine [C], and thymine [T].
The DNA bases store the genetic code, which contains the instructions that a living organism needs to grow, reproduce and function.

CLICK this link to open Jalview and view a fragment of DNA in an adjacent web browser tab

JalviewJS may take a few seconds to open and load the sequence in the adjacent web browser window.
Feel free to play! For example, rotate the 3D structure by placing the mouse cursor on the structure and then move the mouse.
Or place the mouse cursor on the sequence and move the mouse across the different bases.
Look at the status bar in the lower left-hand side of the alignment window as this contains extra information.


Viewing RNA in Jalview

RNA (ribonucleic acid) is a single strand molecule which is much shorter than DNA, its fourth base is uracil [U] not thymine [T].
RNA is responsible for taking the genetic code stored in DNA and using it to make proteins.

CLICK this link to open Jalview and view a riboswitch mRNA in an adjacent web browser tab

Feel free to play!
Rotate the 3D structure by placing the mouse cursor on the structure and then move the mouse.
Place the mouse cursor on the sequence and move the mouse across the different bases.

Q. Look at the letters of the 4 bases in the RNA sequence, which one is different from the DNA bases?


The role of DNA and RNA in maintaining life

This 3D animation shows how proteins are made in the cell from the information in the DNA code.


Why is RNA just as cool as DNA?

Watch the Amoeba Sisters' video as they compare and contrast RNA with DNA and learn why DNA should be sharing the limelight!

"If RNA and DNA were sisters, DNA would be the popular one with a very distinct look. She would be at the top of the class because she knows so much.
Whilst RNA would be the quiet, hardworking one, not easily recognised, but the person who you can rely on to make thing happen."


DNA's double helix

 


What is Jalview?

Jalview is a free computer program that is used to view the sequences and 3D structures of DNA, RNA and proteins.
Jalview can read files directly from public biological databases and has a number of analysis tools for aligning sequences, producing trees and comparing structures.


Why we need software such as Jalview?


Please visit the Jalview’s Schools webpage for more information about using Jalview to visualise DNA, RNA and proteins.