Resources for the Jalview School's Workbook
'Visualising DNA, RNA & Proteins' Jalview School Workbook is aimed at 16-18 year old secondary school students studying Higher or A level biology. The easy-to-use design requires only a desktop or laptop computer with a web browser and internet access. The workbook is made up of 3 projects with their own self-contained exercises.
Project 1 views DNA, RNA and protein sequences and their sub-units, then views the 3D structure of these molecules.
Project 2 views the sequence and 3D structure of human myoglobin protein, compares it with sequences from other species, then views its coding DNA.
Project 3 views exons and introns in the HBB gene, then views the coding DNA and its protein product in a split-screen viewer identifying the genetic mutation responsible for sickle cell anaemia.
(A) School Workbook pdf link
(B) Launching Jalview JS link
Click link to launch JalviewJS in a web browser.
(C) IDs and URLs used in the Workbook
(a) Project 1-Exercise 1 ID: Viewing DNA - 3BSE or else drag DNA file onto Jalview desktop
(b) Project 1-Exercise 2 ID: Viewing RNA - 2GIS or else drag RNAfile onto Jalview desktop
(c) Project 1-Exercise 3 IDs: Viewing proteins -
1smd (amylase - enzyme) or drag amylase file onto Jalview desktop
1cag (collagen - structure) or drag collagen file onto Jalview desktop
1igt (antibody - defence) or drag antibody file onto Jalview desktop
5xb1 (ferritin - storage) or drag ferritin file onto Jalview desktop
6bcx - (insulin - signalling) or drag insulin file onto Jalview desktop [Note: this can take a while to load]
1mbn - (myoglobin -transport) or drag myoglobin file onto Jalview desktop
(d) Project 2-Exercise 1 ID: Viewing myoglobin sequences - p02144 [Uniprot]
Drag Myoglobin-p02144 file URL onto Jalview desktop
Drag Alignment of Myoglobins file URL onto Jalview desktop
(e) Project 2-Exercise 2 ID: Viewing myoglobin & its coding DNA - CAG46747 [EMBLCDS]
(f) Project 3-Exercise 1: Viewing exons & introns in the HBB gene
Drag HBB gene file URL onto Jalview desktop
Drag HBB feature file URL onto Jalview desktop
(g) Project 3-Exercise 2: Viewing coding DNA & its protein product
EMBLCDS data base-->
CAG46711
Drag HBB CDS feature file URL onto Jalview desktop
Drag Protein feature file URL onto Jalview desktop