Resources for the Jalview School's Workbook
'Visualising DNA, RNA & Proteins' Jalview School Workbook is aimed at 16-18 year old secondary school students studying Higher or A level biology. The easy-to-use design requires only a desktop or laptop computer with a web browser and internet access.
The workbook is made up of 3 computer based projects with their own self-contained exercises.
Project 1 views DNA, RNA and protein sequences and their sub-units, then views the 3D structure of these molecules.
Project 2 views the sequence and structure of human myoglobin protein, comparing it with sequences from other species, then viewing its coding DNA.
Project 3 views exons and introns in the HBB gene, then views the coding DNA and its protein product in a split-screen viewer identifying the genetic mutation responsible for sickle cell anaemia.
(A) School Workbook
Click here to view the Schools Workbook
(B) Launching Jalview JS program in a web browser
Click this link to launch JalviewJS
(C) IDs and URLs used in the Workbook
(a) Project 1-Exercise 1 ID: Viewing DNA (3BSE) - drag this DNA file onto Jalview desktop
(b) Project 1-Exercise 2 ID: Viewing RNA (2GIS) - drag this RNA file onto Jalview desktop
(c) Project 1-Exercise 3 IDs: Viewing protein Amylase (1smd enzyme) - drag this amylase file onto Jalview desktop
Collagen (1cag structure) - drag this collagen file onto Jalview desktop
Antibody (1igt defence) - drag this antibody file onto Jalview desktop
Ferritin (5xb1 storage) - drag this ferritin file onto Jalview desktop
Insulin (6bcx signalling) - drag this insulin file onto Jalview desktop [Note: this can take a while to load]
Myoglobin (1mbn transport) - drag this myoglobin file onto Jalview desktop
(d) Project 2-Exercise 1 ID: Viewing myoglobin sequences
Drag Myoglobin-p02144 file URL onto Jalview desktop
Drag Alignment of Myoglobins file URL onto Jalview desktop
(e) Project 2-Exercise 2 ID: Viewing myoglobin & its coding DNA - EMBLCDS database id: CAG46747
(f) Project 3-Exercise 1: Viewing exons & introns in the HBB gene
Drag HBB gene file URL onto Jalview desktop
Drag HBB feature file URL onto Jalview desktop
(g) Project 3-Exercise 2: Viewing coding DNA & its protein product - EMBLCDS database id: CAG46711
Drag HBB CDS feature file URL onto Jalview desktop
Drag Protein feature file URL onto Jalview desktop
Walkthrough Videos
The video walkthroughs are speeded up recordings of each of the exercises in the workbook.
(a) Click to view: Project 1-Exercise 1: Viewing DNA walkthrough video
(b) Click to view: Project 1-Exercise 2: Viewing RNA walkthrough video
(c) Click to view: Project 1-Exercise 3: Viewing proteins walkthrough video
(d) Click to view: Project 2-Exercise 1: Viewing myoglobin protein walkthrough video
(e) Click to view: Project 2-Exercise 2: Viewing myoglobin and coding DNA walkthrough video
(f) Click to view: Project 3-Exercise 1: Viewing exons and introns walkthrough video
(g) Click to view: Project 3-Exercise 2: Viewing coding DNA and its protein product walkthrough video
Other Videos
(i) What is Jalview?
(ii) Jalview- free software for multiple sequence alignment and analysis
(iii) Navigating the Jalview desktop
(iv) Click to view the video: Jalview's multiple windows
(v) Click to view the video: Jalview's drop-down and context menus