Resources for the Jalview School's Workbook
'Visualising DNA, RNA & Proteins' Jalview School Workbook is aimed at 16-18 year old secondary school students studying Higher or A level biology. The easy-to-use design requires only a desktop or laptop computer with a web browser and internet access.
The workbook is made up of 3 computer based projects with their own self-contained exercises.
Project 1 views DNA, RNA and protein sequences and their sub-units, then views the 3D structure of these molecules.
Project 2 views the sequence and structure of human myoglobin protein, comparing it with sequences from other species, then viewing its coding DNA.
Project 3 views exons and introns in the HBB gene, then views the coding DNA and its protein product in a split-screen viewer identifying the genetic mutation responsible for sickle cell anaemia.
(A) School Workbook
(B) Launching Jalview JS program in a web browser
Click this link to launch JalviewJS
(C) IDs and URLs used in the Workbook
(a) Project 1-Exercise 1 ID: Viewing DNA (3BSE) - drag this DNA file onto Jalview desktop
(b) Project 1-Exercise 2 ID: Viewing RNA (2GIS) - drag this RNA file onto Jalview desktop
(c) Project 1-Exercise 3 IDs: Viewing protein Amylase (1smd enzyme) - drag this amylase file onto Jalview desktop
Collagen (1cag structure) - drag this collagen file onto Jalview desktop
Antibody (1igt defence) - drag this antibody file onto Jalview desktop
Ferritin (5xb1 storage) - drag this ferritin file onto Jalview desktop
Insulin (6bcx signalling) - drag this insulin file onto Jalview desktop [Note: this can take a while to load]
Myoglobin (1mbn transport) - drag this myoglobin file onto Jalview desktop
(d) Project 2-Exercise 1 ID: Viewing myoglobin sequences
(e) Project 2-Exercise 2 ID: Viewing myoglobin & its coding DNA - EMBLCDS database id: CAG46747
(f) Project 3-Exercise 1: Viewing exons & introns in the HBB gene
(g) Project 3-Exercise 2: Viewing coding DNA & its protein product - EMBLCDS database id: CAG46711
The video walkthroughs are speeded up recordings of each of the exercises in the workbook.
(a) Click to view: Project 1-Exercise 1: Viewing DNA walkthrough video
(b) Click to view: Project 1-Exercise 2: Viewing RNA walkthrough video
(c) Click to view: Project 1-Exercise 3: Viewing proteins walkthrough video
(d) Click to view: Project 2-Exercise 1: Viewing myoglobin protein walkthrough video
(e) Click to view: Project 2-Exercise 2: Viewing myoglobin and coding DNA walkthrough video
(f) Click to view: Project 3-Exercise 1: Viewing exons and introns walkthrough video
(g) Click to view: Project 3-Exercise 2: Viewing coding DNA and its protein product walkthrough video
(i) What is Jalview?
(iv) Click to view the video: Jalview's multiple windows
(v) Click to view the video: Jalview's drop-down and context menus